Vincent follows the work of a private detective agency based in Manchester, run by private investigator Vincent Gallagher (Ray Winstone), who alongside his sidekick Beth (Suranne Jones), junior PI Robert (Joe Absolom) and fellow team members Gillian (Angel Coulby) and John (Ian Puleston-Davies), investigates cases which the police would either refuse to touch, or have been unable to solve. Vincent also has to deal with his arch enemy, DCI David Driscoll (Philip Glenister), who begins a relationship with his estranged wife Cathy (Eva Pope), resulting in Cathy becoming pregnant.